"Bacteriocins: a Promising Alternative to Combat Pathogenic Bacteria"

Sara Fawzi Sahm

Abstract

Many societies have long used LAB-containing fermented foods on a daily basis. Most southern Indian households use curd, which is manufactured by fermenting milk with an inoculum of previously made curd, as a major component of their daily meal. Since there is no standard starter culture for making curd, the LAB that ferments the milk may probably vary slightly from household to household. Even though curd is thought to contain probiotic qualities.


Bacteriocins are antimicrobial peptides produced by variety bacteria that exhibit potent activity against a broad range of pathogenic microorganisms. With the rise of antibiotic resistance, bacteriocins have garnered attention as a promising alternative to traditional antibiotics. Bacteriocins produced by Lactobacillus species are increasingly recognized for their potent antimicrobial activity and potential as natural preservatives and therapeutic agents. Current research explores the potential of bacteriocin as effective biotherapeutics against pathogenic bacteria, along with combinational use with convectional antibiotics to overcome drug resistance concern. In this study partially purified bacteriocin is obtained by ammonium sulphate fractional precipitation and purity of bacteriocin is achieved by using column chromatography and SDS-PAGE technique.


In conclusion, these studies contribute to our growing understanding of bacteriocins and their potential as natural alternatives to traditional antibiotics. We have been able to decipher the complex nuances of this bacteriocin's capabilities through the use of molecular, biochemical, and biophysical approaches. This has laid the groundwork for future studies in fields including food preservation, medical treatments, and bio preservation.

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Sara Fawzi Sahm
Sahm, S. F. (2025). "Bacteriocins: a Promising Alternative to Combat Pathogenic Bacteria". World of Medicine : Journal of Biomedical Sciences, 2(1), 150–160. Retrieved from https://wom.semanticjournals.org/index.php/biomed/article/view/257
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