Comparative Characteristics of the Morphometric Parameters of the Kidney in Polypharmacy with Anti-Inflammatory Drugs

Abstract

At the global level, there has been an increase in the number of diseases caused by disorders of the urinary system. The studies were carried out on 250 five-month-old outbred white rats. This article studied changes in the morphometric parameters of the kidney under conditions of polypharmacy with 5 types of anti-inflammatory drugs. Polypharmacy of anti-inflammatory drugs had a negative effect on the morphometric parameters of the structural elements of the kidney. As a result of polypharmacy, the area of the renal corpuscle increased (up to 6.23%), the area of the cavity of the renal capsule (up to 12.36%), the area of the renal corpuscle (up to 7.04%), proximal (up to 8.27%) and distal caused a decrease the diameter of the convoluted tubules (up to 8.77%).