Malignant Neuroendocrine Tumors and Radioisotope Research: A Vision of Innovative Theurapeutic Methods and Rational Development of Targeted Therapy

Radionuclide Theraphy NET

Authors

  • Elene Vardosanidze Tbilisi State Medical University, Faculty of Public Health, Tbilisi, Georgia
  • Keti Kebadze Tbilisi State Medical University, Faculty of Medicine Tbilisi, Georgia
  • Mariam Gigiadze Tbilisi State Medical University, Faculty of Medicine Tbilisi, Georgia
  • Mariam Beriashvili Tbilisi State Medical University, Faculty of Medicine Tbilisi, Georgia
  • Liza Mariamidze Tbilisi State Medical University, Faculty of Medicine Tbilisi, Georgia
  • Mariam Dzidziguri Gastroenterology resident, Lecturer at Davit Tvildiani Medical University, Tbilisi, Georgia
  • Erekle Gigiadze M.D, Ph.D, Radiologist at K.eristavi National Center of Experimental and Clinical Surgery Tbilisi, Georgia
May 20, 2025

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Neuroendocrine tumors (NETs) are a group of uncommon tumors that start in your neuroendocrine cells. These cells combine the traits of nerve cells and hormone-producing cells. Most neuroendocrine tumors are malignant .There are several types of neuroendocrine tumors with symptoms that are easy to mistake for other less serious conditions. The characteristics of NETs including how aggressive (fast-growing) they are, the symptoms they cause and what treatments work best — vary significantly based on the tumor.

Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and remarkable transformation. Emerging as fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, and gene therapy.