Juvenile Dysmenorrhea: Innovative Approaches to Differential Diagnosis and Treatment with a Focus on Hormonal and Connective Tissue Factors

Abstract

In this article, the author examines newly developed diagnostic and therapeutic strategies in juvenile dysmenorrhea that is characterized by painful menstruation in women aged 14 to 25 and significantly influences their quality of life. In regard to dysmenorrhea problem, the study considers hormonal factors, connective tissue dysplasia (CTD), and genetic predispositions as some of the most important physiological and genetic causes. A group of 230 females aged 12–18 years was clinically assessed, hormone levels as well as biochemical and genetic data were investigated. The results provide the evidence of significant link between CTD markers including joint hypermobility and vascular abnormalities on one side and increased pain processing on the other. Estrogen and progesterone receptors, polymorphism, increase the severity of symptomatology and are clearly connected with hormonal imbalance. It is for this reason that the combined evaluations of CTD assessments hormonal and genetics should be incorporated into the diagnostic models to boost their accuracy and enable development of specific treatment plans. This study is especially significant as it proposes to move from a treatment based model that targets only manifestations of ill health in the feminine reproductive system to a more causal approach that seeks to identify causes of intimate feminine illness and disease for timely prevention so that long term reproductive health complications do not set in. Using precise techniques in the methodologies, this article intends to come up with various solutions to the problems affecting adolescent health and especially to those living in Uzbekistan where issues to do with reproductive healthy are some of the most sensitive. These findings were in harmony with the advancement of personalized medicine around the globe for the diagnosis and overall management of juvenile dysmenorrhea with better patient prognosis.