The Association between Type 2 Diabetes Mellitus and Some Immunological Parameters (IL-6, C3, Igg, WBC)

Abstract

The study aimed to establish the connection between type 2 diabetes mellitus and IL-6, C3, IgG, and WBC in clinically diagnosed diabetes patients. Using a cross-sectional design, we compared the immunological parameters of 121 Iraqis from Basra City having type 2 diabetes mellitus with 50 healthy control people. Serum concentrations of total IgG and third complement compound C3 were determined by the turbidimetric method using Gesan production S. R. l-Italy. Piccolo chem. Serum concentrations of IL-6 were determined using enzyme-linked immune sorbent assay (ELISA). The CBC was measured. Demographic and laboratory data were distinguished. Our data indicated that type 2 diabetes was strongly associated with elevated levels of IL-6, C3, and WBC, with no significant difference in the IgG levels. Unregulated blood sugar levels change the normal concentration of immunological parameters, leading to an altered immune response in diabetic patients.