Assessment of Cytotoxic Potentials of Styrax Officinalis (Styracaceae) Extracts from Jordan against Human Cancer Cell Lines
Abstract
Plants of Styrax officinalis are members of the family Styracaceae, which comprises small trees or shrubs. It is predominant in the Mediterranean region. The leaves of this plant exhibit active phytochemical compounds with antioxidant properties. This project aims to examine the cytotoxic effect of aqueous and methanolic extracts of the leaves of Styrax officinalis on two selected human cancer cell lines: mammary gland carcinoma (MCF7), human hepatocellular liver carcinoma (HepG2) in addition to the noncancerous cell line fibroblast. In vitro, the cytotoxic activity of aqueous and methanolic extracts of leaves of S. officinalis was investigated against three cell lines: MCF-7, HepG2, and fibroblast, and the outcomes of this study showed that the highest cytotoxic activity was revealed in methanolic extract of leaves against MCF-7 and HepG2 with IC50 values of 14.95μg/ml and 19.39μg/ml respectively.