Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity

This study included the preparation of a pentameric ring derived from tetrazole by reacting previously prepared Schiff bases with sodium azide in the presence of dioxane as a solvent. The structures were validated using physical measurements. From the melting point, colour change, and product ratio, spectroscopic analyses were used, including proton nuclear magnetic resonance and infrared spectroscopy. These compounds were also prepared against two types of bacteria, gram-positive and gram-negative. The molecular docking of some compounds M7 and M9 with proteins derived from E. Coli bacteria was also studied.